Interfaces and prostheses, whether physical, visual, or virtual, are more and more characterized by an ever-increasing level of complexity. In this designing scenario, the relationship with cognitive sciences, ergonomics, semiotics, and the contribution of enabling technologies is transforming the field of product design into that of the design of complex systems that interface the relationship between human and machine. This paper, starting from the analysis of fiction, scientific literature, and state of the art, analyses the imaginary vision of man-cyborg and the transformation of his body by integrating and becoming dependent on technology to open a debate on a new design relationship between the body and digital artifacts. A new scena...