Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
- Perry, John R.B.
- Stolk, Lisette
- Franceschini, Nora
- Lunetta, Kathryn L.
- Zhai, Guangju
- McArdle, Patrick F.
- Smith, Albert V.
- Aspelund, Thor
- Bandinelli, Stefania
- Boerwinkle, Eric
- Cherkas, Lynn
- Eiriksdottir, Gudny
- Estrada, Karol
- Ferrucci, Luigi
- Folsom, Aaron R.
- Garcia, Melissa
- Gudnason, Vilmundur
- Hofman, Albert
- Karasik, David
- Kiel, Douglas P.
- Launer, Lenore J.
- Van Meurs, Joyce
- Nalls, Michael A.
- Rivadeneira, Fernando
- Shuldiner, Alan R.
- Singleton, Andrew
- Soranzo, Nicole
- Tanaka, Toshiko
- Visser, Jenny A.
- Weedon, Michael N.
- Wilson, Scott G.
- Zhuang, Vivian
- Streeten, Elizabeth A.
- Harris, Tamara B.
- Murray, Anna
- Spector, Tim D.
- Demerath, Ellen W.
- Uitterlinden, André G.
- Murabito, Joanne M.
Publication date
January 2009
DOIAbstract
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10−9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10−9), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation
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