Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
- Perry, JRB
- Stolk, Lisette
- Franceschini, N
- Lunetta, KL
- Zhai, GJ
- McArdle, PF
- Smith, AV
- Aspelund, T
- Bandinelli, S
- Boerwinkle, E
- Cherkas, L
- Eiriksdottir, G
- Estrada Gil, Karol
- Ferrucci, L
- Folsom, AR
- Garcia, M
- Gudnason, V
- Hofman, Bert
- Karasik, D
- Kiel, DP
- Launer, LJ (Lenore)
- van Meurs, Joyce
- Nalls, MA
- Rivadeneira, Fernando
- Shuldiner, AR
- Singleton, A
- Soranzo, N
- Tanaka, T
- Visser, Jenny
- Weedon, MN
- Wilson, SG
- Zhuang, V
- Streeten, EA
- Harris, TB
- Murray, A
- Spector, TD
- Demerath, EW
- Uitterlinden, André
- Murabito, JM
Publication date
January 2009
DOIAbstract
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation
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