A second generation synthesis of (?)-luminacin D based on an early stage introduction of the trisubstituted epoxide group is reported, allowing access to the natural product in an improved yield and a reduced number of steps (5.4%, 17 steps vs 2.6%, 19 steps). A full account of the optimization work is provided, with the reversal of stereoselection in the formation of the C4 alcohol in equally excellent diastereoselectivity as key improvement
Organic chemistry is an exploratory world in which chemists translate their knowledge by creating ne...
This article provides a detailed report of our efforts to synthesize the dithiodiketopiperazine (DTP...
Total synthesis of the pyrrolic marine natural products lukianols A (1) and B (2) has been achieved ...
A second-generation synthesis of (−)-luminacin D based on an early stage introduction of the trisubs...
A second-generation synthesis of (-)-luminacin D based on an early stage introduction of the trisubs...
Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes t...
A proposed strategy for the enantioselective total synthesis of luminacin D, one of a family of 14 s...
[GRAPHICS]A series of structurally simplified luminacin analogues devoid of the epoxide ring are ass...
Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes t...
Luminacin D belongs to a family of bioactive compounds isolated from the fermentation broth of soil ...
A 15-step synthesis of (+/-)-luminacin D from ethyl pent-2-ynoate is reported. The pivotal step invo...
This article describes the first total synthesis of luminamicin using a strategy combining chemical ...
The authors would like to acknowledge EPSRC for PhD funding through the Doctoral Training Schemes.Th...
Derivatives of Lavendamycin, an antitumor antibiotic natural product, were synthesized via short and...
The synthesis of the recently discovered angiogenesis inhibitors epoxyquinols A and B, having novel ...
Organic chemistry is an exploratory world in which chemists translate their knowledge by creating ne...
This article provides a detailed report of our efforts to synthesize the dithiodiketopiperazine (DTP...
Total synthesis of the pyrrolic marine natural products lukianols A (1) and B (2) has been achieved ...
A second-generation synthesis of (−)-luminacin D based on an early stage introduction of the trisubs...
A second-generation synthesis of (-)-luminacin D based on an early stage introduction of the trisubs...
Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes t...
A proposed strategy for the enantioselective total synthesis of luminacin D, one of a family of 14 s...
[GRAPHICS]A series of structurally simplified luminacin analogues devoid of the epoxide ring are ass...
Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes t...
Luminacin D belongs to a family of bioactive compounds isolated from the fermentation broth of soil ...
A 15-step synthesis of (+/-)-luminacin D from ethyl pent-2-ynoate is reported. The pivotal step invo...
This article describes the first total synthesis of luminamicin using a strategy combining chemical ...
The authors would like to acknowledge EPSRC for PhD funding through the Doctoral Training Schemes.Th...
Derivatives of Lavendamycin, an antitumor antibiotic natural product, were synthesized via short and...
The synthesis of the recently discovered angiogenesis inhibitors epoxyquinols A and B, having novel ...
Organic chemistry is an exploratory world in which chemists translate their knowledge by creating ne...
This article provides a detailed report of our efforts to synthesize the dithiodiketopiperazine (DTP...
Total synthesis of the pyrrolic marine natural products lukianols A (1) and B (2) has been achieved ...