Studies on carcinogenesis in hamsters.

The studies on carcinogenesis in hamsters represent actually a relatively new field of development. Gye and Foulds were the first to induce experimentally sarcomas in hamsters in 1940. This was followed by sporadic work of Ashbell (1945) and Shrader (1946), who reported on spontaneous tumors in hamsters, and that of Crabb, who induced sarcomas by injection of 9, 10 dimethyl 1, 2 benzanthracene in 1946. The extensive studies of carcinogenesis were initiated by the work of Kirkman and Bacon (1952), who reported the effects of various hormonal factors in male and gonadectomized female hamsters