Induction of Tumors in Hamsters by Rat Rous Sarcoma RBI, Producing Chick Sarcoma Virus. I. Continuous Production of Virus Oncogenic for Chicks by Hamster Sarcoma

SUMMARY-RBI rat sarcoma cells, producing viruspathogenic for chickens, induced sa'rcomas in hamsters. These sarcomas were designated RBH. A double heteroinduction, i.e., chicken-rat, rat-hamster, took place. The RBH tumor was transplantable in hamsters. RBH hamster sarcoma cells and virus preparations isolated from them induced sarcomas in chickens. The logarithms of 1050 values were from 1.9-3.7. RBH cells adapted to growth in tissue culture, termed RBHt e, also were transplantable in hamsters. RBHt c cells continuously released a virus infectious to chickens. The chromosomal investigation of RBH and RBHt c cells indicated thei