Toxicity of fluoride in liver of Albino rat and Mitigation after adopting artificial (Vitamin C and D) and natural (Aloe vera) food supplementations. SHWETA PARIHAR* ANIL CHOUDHARY, & SHALINI GAUR *K.N.GIRLS COLLEGE OF JODHPUR DEPARTMENT OF ZOOLOGY

ABSTRACT:-Fluoride is a widespread non biodegradable and relatively persistent pollutant, which at low levels of contamination causes serious health problems difficult to cure. Fluoride pollution in India is mainly due to natural sources reported so far. Its concentration in water is much higher than the recommended values by different authorities. More than half a million people are affected by the disease called fluorosis which is due to chronic fluoride intoxication. Fluoride toxicity is characterized by a variety of signs and symptoms.Poisoining most commonly occurs following ingestion either accidental or intentional of fluoride containing products. In present study effects of oral administration of sodium fluoride(Naf) at a dose of 10mg/l of Naf per kg of body weight for 30, 60 & 90 days respectively were investigated in liver of mice.Naf treatment resulted in liver few focal areas, necrosis of hepatic cells were observed along with proliferation of hepatic cords. These changes were appeared after exposing rats to 10mg/l of sodium fluoride per kg of body weight for 30 days. While after 60 days of treatment, the normal lobular pattern of hepatic cords start distorted showing degenerative changes with necrosis and hepatic cells in certain areas were found to be vacuolated. After 90 days treatment enlarged & dilated hepatic vein were observed along with degeneration of hepatocyte with and excessive hepatic cell necrosis. These changes were recovered too much extent after withdrawal of Naf and mitigated by Artificial source (vitamin C & D) and Natural source (Aloe vera) food supplementation