Sodium Fluoride Toxicity on Reproductive Organs of Female Albino Rats

Abstract: Fluorosis is a dreaded disease caused due to high fluoride (>1.5 ppm) in drinking water. In the present study normal cyclic female rats (Rattus norvegicus), weighing between 150- 200 gm, were kept on sodium fluoride (6ppm) water for 15 and 30 days. The results revealed that the fluoride water exposure to female rats caused irregular estrus cycle, reduced fertility rate, number of litters, weights of reproductive organs ( ovary, uterus, vagina) and adrenal gland, concentration of protein (ovary, uterus, adrenal and liver), ascorbic acid (adrenal), enzyme activity of acid phosphatase (ovary and uterus), serum enzyme activity of acid phosphatase, where as alkaline phosphatase, SGOT, SGPT in serum, cholesterol (ovary, uterus, adrenal), glycogen (ovary, uterus, liver) and ascorbic acid content of ovary and uterus increased significantly as compared to control value. However haematological parameters were found to be within normal range. The data suggests that sodium fluoride water exposure for 15 and 30 days caused adverse effect on reproductive organs, leading to reduced fertility and number of litter in female albino rats