Effect of Fluoride Contaminated Drinking Water in Albino Rats Rattus norvegicus

Abstract: Healthy, adult albino rats were treated with fluoride water (1.5, 3, 4.5, 6 ppm) for 60 days. The data reveal that reduction in weight of kidney was observed after the ingestion 3 and 6 ppm of fluoride water. The haematological parameters found to be altered with higher dose of fluoride water leading to anaemic condition. The serum protein, cholesterol and phospholipids were reduced in all the groups studied. However no change was observed in enzyme activity of serum alkaline phosphatase. The tissue biochemistry (glycogen, cholesterol, ascorbic acid) of liver, heart, kidney and adrenal diminished following fluoride water treatment. The data suggests that excess fluoride water exposure to rats caused reduction in weight of kidney, altered serum and tissue biochemistry in turn causing toxic effects on liver, heart, kidney and adrenal