Some protein design tasks cannot be modeled by the traditional single state design strategy of finding a sequence that is optimal for a single fixed backbone. Such cases require multistate design, where a single sequence is threaded onto multiple backbones (states) and evaluated for its strengths and weaknesses on each backbone. For example, to design a protein that can switch between two specific conformations, it is necessary to to find a sequence that is compatible with both backbone conformations. We present in this paper a generic implementation of multistate design that is suited for a wide range of protein design tasks and demonstrate in silico its capabilities at two design tasks: one of redesigning an obligate homodimer into an obl...
Computer-based methods are excellent tools to modify existing proteins. The software suite Rosetta o...
To facilitate the design of protein sequences with desired properties, simulation techniques have be...
Interactions in protein networks may place constraints on protein interface sequences to maintain co...
Some protein design tasks cannot be modeled by the traditional single state design strategy of findi...
Some protein design tasks cannot be modeled by the traditional single state design strategy of findi...
Most successes to date in computational protein design have relied on optimizing sequences to fit we...
Most of the methods that have been developed for computational protein design involve the selection ...
The stability, activity, and solubility of a protein sequence are determined by a delicate balance o...
Traditional computational protein design (CPD) calculations model sequence perturbations and evaluat...
International audienceMOTIVATION:Structure-based Computational Protein design (CPD) plays a critical...
Computational protein design has found great success in engineering proteins for thermodynamic stabi...
A challenge in the structure-based design of specificity is modeling the negative states, i.e., the ...
SummaryProtein design tests our understanding of protein stability and structure. Successful design ...
Computational protein design aims to predict protein sequences that will fold into a given three-dim...
Computational protein design has found great success in engineering proteins for thermo-dynamic stab...
Computer-based methods are excellent tools to modify existing proteins. The software suite Rosetta o...
To facilitate the design of protein sequences with desired properties, simulation techniques have be...
Interactions in protein networks may place constraints on protein interface sequences to maintain co...
Some protein design tasks cannot be modeled by the traditional single state design strategy of findi...
Some protein design tasks cannot be modeled by the traditional single state design strategy of findi...
Most successes to date in computational protein design have relied on optimizing sequences to fit we...
Most of the methods that have been developed for computational protein design involve the selection ...
The stability, activity, and solubility of a protein sequence are determined by a delicate balance o...
Traditional computational protein design (CPD) calculations model sequence perturbations and evaluat...
International audienceMOTIVATION:Structure-based Computational Protein design (CPD) plays a critical...
Computational protein design has found great success in engineering proteins for thermodynamic stabi...
A challenge in the structure-based design of specificity is modeling the negative states, i.e., the ...
SummaryProtein design tests our understanding of protein stability and structure. Successful design ...
Computational protein design aims to predict protein sequences that will fold into a given three-dim...
Computational protein design has found great success in engineering proteins for thermo-dynamic stab...
Computer-based methods are excellent tools to modify existing proteins. The software suite Rosetta o...
To facilitate the design of protein sequences with desired properties, simulation techniques have be...
Interactions in protein networks may place constraints on protein interface sequences to maintain co...