Add to ORKGA straightforward synthesis of topopyrones B and D is described. The key reaction involved a convergent avenue to the anthraquinone core utilizing a tandem directed ometalation - metal halogen exchange methodology. The chemistry should be suitable for future SAR studies.Science, Faculty ofChemistry, Department ofGraduat
Topoisomerases are enzymes which alter the topological state of DNA. Mammalian type I and II topoiso...
The following dissertation describes the design, preparation, and bioassay of several classes of top...
The synthesis of a new hexacyclic system was realized starting from tryptamines and exploiting as a ...
A straightforward synthesis of topopyrones B and D is described. The key reaction involved a converg...
The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been c...
Structure–activity studies were employed to investigate the stabilization of DNA–topoisomerases I an...
The development of new methodologies for the synthesis of substituted pyrroles has been encouraged b...
The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spe...
A series of structurally simple analogues of natural topopyrone C were synthesized and tested for cy...
Anthraquinone peptide derivatives have previously been shown to inhibit the enzyme topoisomerase I (...
International audienceIn search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, ...
In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]qui...
Ce travail a pour objet la synthèse et l’évaluation de molécule bioactives pouvant contribuer effica...
Currently, the only topoisomerase I (top1) inhibitors approved by the U.S. Food and Drug Administrat...
Our group is studying fluorinated acridone derivatives for the first time, for their potential as to...
Topoisomerases are enzymes which alter the topological state of DNA. Mammalian type I and II topoiso...
The following dissertation describes the design, preparation, and bioassay of several classes of top...
The synthesis of a new hexacyclic system was realized starting from tryptamines and exploiting as a ...
A straightforward synthesis of topopyrones B and D is described. The key reaction involved a converg...
The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been c...
Structure–activity studies were employed to investigate the stabilization of DNA–topoisomerases I an...
The development of new methodologies for the synthesis of substituted pyrroles has been encouraged b...
The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spe...
A series of structurally simple analogues of natural topopyrone C were synthesized and tested for cy...
Anthraquinone peptide derivatives have previously been shown to inhibit the enzyme topoisomerase I (...
International audienceIn search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, ...
In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]qui...
Ce travail a pour objet la synthèse et l’évaluation de molécule bioactives pouvant contribuer effica...
Currently, the only topoisomerase I (top1) inhibitors approved by the U.S. Food and Drug Administrat...
Our group is studying fluorinated acridone derivatives for the first time, for their potential as to...
Topoisomerases are enzymes which alter the topological state of DNA. Mammalian type I and II topoiso...
The following dissertation describes the design, preparation, and bioassay of several classes of top...
The synthesis of a new hexacyclic system was realized starting from tryptamines and exploiting as a ...