The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been carried out by Marschalk alkylation of 1-hydroxy-3,6,8-trimethoxyanthraquinone, followed by a Baker–Venkataraman chain elongation and an acid-catalyzed cyclization for the construction of the pyrone ring
The present work deals with the synthesis of topoisomerase I and II inhibitors. The aim of our work ...
Anthraquinone peptide derivatives have previously been shown to inhibit the enzyme topoisomerase I (...
Our group is studying fluorinated acridone derivatives for the first time, for their potential as to...
A straightforward synthesis of topopyrones B and D is described. The key reaction involved a converg...
A series of structurally simple analogues of natural topopyrone C were synthesized and tested for cy...
The development of new methodologies for the synthesis of substituted pyrroles has been encouraged b...
Structure–activity studies were employed to investigate the stabilization of DNA–topoisomerases I an...
The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spe...
Topoisomerases are enzymes which alter the topological state of DNA. Mammalian type I and II topoiso...
Ce travail a pour objet la synthèse et l’évaluation de molécule bioactives pouvant contribuer effica...
The following dissertation describes the design, preparation, and bioassay of several classes of top...
Benzonaphthofurandiones containing four coplanar fused aromatic rings were synthesized and evaluated...
The synthesis of a new hexacyclic system was realized starting from tryptamines and exploiting as a ...
The first total synthesis of three naturally occurring cyclophane derivatives belonging to the turri...
A new method for the synthesis of the [4,3,1] carbocyclic core of the squalene synthase and farnesyl...
The present work deals with the synthesis of topoisomerase I and II inhibitors. The aim of our work ...
Anthraquinone peptide derivatives have previously been shown to inhibit the enzyme topoisomerase I (...
Our group is studying fluorinated acridone derivatives for the first time, for their potential as to...
A straightforward synthesis of topopyrones B and D is described. The key reaction involved a converg...
A series of structurally simple analogues of natural topopyrone C were synthesized and tested for cy...
The development of new methodologies for the synthesis of substituted pyrroles has been encouraged b...
Structure–activity studies were employed to investigate the stabilization of DNA–topoisomerases I an...
The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spe...
Topoisomerases are enzymes which alter the topological state of DNA. Mammalian type I and II topoiso...
Ce travail a pour objet la synthèse et l’évaluation de molécule bioactives pouvant contribuer effica...
The following dissertation describes the design, preparation, and bioassay of several classes of top...
Benzonaphthofurandiones containing four coplanar fused aromatic rings were synthesized and evaluated...
The synthesis of a new hexacyclic system was realized starting from tryptamines and exploiting as a ...
The first total synthesis of three naturally occurring cyclophane derivatives belonging to the turri...
A new method for the synthesis of the [4,3,1] carbocyclic core of the squalene synthase and farnesyl...
The present work deals with the synthesis of topoisomerase I and II inhibitors. The aim of our work ...
Anthraquinone peptide derivatives have previously been shown to inhibit the enzyme topoisomerase I (...
Our group is studying fluorinated acridone derivatives for the first time, for their potential as to...
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