Benzonaphthofurandiones containing four coplanar fused aromatic rings were synthesized and evaluated for their cytotoxicity against five human cancer cell lines, and their inhibitory activity on topoisomerases. These benzonaphthofurandiones were prepared by condensation of 2,3-dichloronaphthoquinone and three aromatic diols with base catalysts in alcohol. The synthesized compounds were o-alkylated with six dialkylaminoalkyl halides. The hydroxy derivatives (8a-8g) exhibited relatively potent cytotoxicity among the prepared compounds. These compounds were evaluated as excellent inhibitors against topoisomerase II (topo II). Especially, the hydroxy analogue with branched methyl side chain (8e) showed high cytotoxicity against cancer cell line...
To examine the effect of hydrophobicity on the anticancer activity of 1,4-naphthoquinone derivative...
A novel series of topoisomerase I (Top I) inhibitors were designed on the basis of camptothecin usin...
New benzothiopyranoindoles (5a-l) and pyridothiopyranoindoles (5m-t), featuring different combinatio...
An unpredicted condensation of naphthylamine with two molecules of ethyl propiolate yields directly ...
© 2020 The Royal Society of Chemistry. Using flavonoids and dichlone as substrates, benzonaphthofuro...
The 7-azaindenoisoquinolines are cytotoxic topoisomerase I (Top1) inhibitors. Previously reported re...
Current quinone anticancer agents such as the anthracyclines are polycyclic conjugated molecules whi...
Three groups of non-camptothecin compounds with four to five fused rings have been designed and synt...
A series of structurally simple analogues of natural topopyrone C were synthesized and tested for cy...
DNA topoisomerases I and II are an actractive target for cancer treatment, because the inhibition of...
Following two orthogonal synthetic routes, a series of all four possible A-ring amino derivatives of...
A series of 3-acyl derivatives of the dihydronaphtho[2,3-b]thiophen-4,9-dione system were studied wi...
Eleven 2,3-(substituted)-1,4-naphthoquinone derivatives were synthesized in yields ranging from 52-8...
A series of 3-acyl derivatives of the dihydronaphtho[2,3-b]thiophen-4,9-dione system were studied wi...
A series of 3-acyl derivatives of the dihydronaphtho[2,3-b]thiophen-4,9-dione system were studied wi...
To examine the effect of hydrophobicity on the anticancer activity of 1,4-naphthoquinone derivative...
A novel series of topoisomerase I (Top I) inhibitors were designed on the basis of camptothecin usin...
New benzothiopyranoindoles (5a-l) and pyridothiopyranoindoles (5m-t), featuring different combinatio...
An unpredicted condensation of naphthylamine with two molecules of ethyl propiolate yields directly ...
© 2020 The Royal Society of Chemistry. Using flavonoids and dichlone as substrates, benzonaphthofuro...
The 7-azaindenoisoquinolines are cytotoxic topoisomerase I (Top1) inhibitors. Previously reported re...
Current quinone anticancer agents such as the anthracyclines are polycyclic conjugated molecules whi...
Three groups of non-camptothecin compounds with four to five fused rings have been designed and synt...
A series of structurally simple analogues of natural topopyrone C were synthesized and tested for cy...
DNA topoisomerases I and II are an actractive target for cancer treatment, because the inhibition of...
Following two orthogonal synthetic routes, a series of all four possible A-ring amino derivatives of...
A series of 3-acyl derivatives of the dihydronaphtho[2,3-b]thiophen-4,9-dione system were studied wi...
Eleven 2,3-(substituted)-1,4-naphthoquinone derivatives were synthesized in yields ranging from 52-8...
A series of 3-acyl derivatives of the dihydronaphtho[2,3-b]thiophen-4,9-dione system were studied wi...
A series of 3-acyl derivatives of the dihydronaphtho[2,3-b]thiophen-4,9-dione system were studied wi...
To examine the effect of hydrophobicity on the anticancer activity of 1,4-naphthoquinone derivative...
A novel series of topoisomerase I (Top I) inhibitors were designed on the basis of camptothecin usin...
New benzothiopyranoindoles (5a-l) and pyridothiopyranoindoles (5m-t), featuring different combinatio...