Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors
- Zhang, Chao
- Li, Shasha
- Ji, Liyan
- Liu, Shan
- Li, Zhongjun
- Li, Shuchun
- Meng, Xiangbao
Publication date
January 2015
DOI Publisher
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS ISSN
0960-894X Journal
issn:1464-3405 Citation count (estimate)
6Abstract
Three groups of non-camptothecin compounds with four to five fused rings have been designed and synthesized. Their in vitro anti-proliferative activity has been evaluated with five different cancer cell lines (HCT116, PC3, U87MG, HepG2, SK-OV-3). Compounds B-2 and B-3 showed the most potent cell growth inhibition with IC50 of 169 nM and 325 nM against U87MG cell line correspondingly. (C) 2015 Elsevier Ltd. All rights reserved.National Natural Science Foundation of China (NSFC) [81273370]SCI(E)PubMedARTICLExbmeng@bjmu.edu.cn204693-46962
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