International audienceThis book discusses the construction of triangulated categories of mixed motives over a noetherian scheme of finite dimension, extending Voevodsky's definition of motives over a field. In particular, it is shown that motives with rational coefficients satisfy the formalism of the six operations of Grothendieck. This is achieved by studying descent properties of motives, as well as by comparing different presentations of these categories, following and extending insights and constructions of Deligne, Beilinson, Bloch, Thomason, Gabber, Levine, Morel, Voevodsky, Ayoub, Spitzweck, R\"ondigs, {\O}stv{\ae}r, and others. In particular, the relation of motives with $K$-theory is addressed in full, and we prove the absolute pu...