International audienceThe Mediterranean realm in Southeast France is located between three mountainous regions (Alps, Pyrenees and Massif-Central) and divided by a main north-south river and valley named The Rhône. The hydrological basin of this river is very important and presently the influence of the Mediterranean climate is sensitive higher in this Rhône’ corridor. These geomorphological features condition some partitioning, with two sub-regions (Provence at east of Rhone, and Occitanie at west), as well as a wide coastal plains and more elevated zones at the border of reliefs. In this contribution we will propose a synthetic view and multi-approaches studies (paleontology, paleoecology, biogeography, ecometry…) about the large mammalia...