Red-jambo peel extract shows antiproliferative activity against HepG2 human hepatoma cells.

The peel of thered-jambo concentrates lhe majority of the btoactive compounds and anüoxidant capacíty of the fruít. Mínor phenolíc compounds i.n thís pari of the fruít are stílí unknown, as well as rhe effect of its extracts in ín vuro and in vivo studies, In an ethanolic extract of red-jambo. a wider range cf phenolíc compounds was tnvestígated and the antíoxidant cellular antíoxídant activity and inhtbitiou of HepG2 cell proliferation were evaluated for the first time. Usíng HPLC·FLDIDAD for phenolíc cornpounds dctermlnatíon, gallíc acid, chlorogeníc actd and (- j-epígallocatechín gallate were found for the OOt time lu the peel of ili" red-jambo fruit, Til" anthocyaníns found (cyanidin 3,5-digItlcoside. cyanidin 3-g1ucoside and peonídín 3-g1ucoside) were the flavonoid class strongly correlated with me annoxídant capacíty methods used ia this study (cellular aatíoxidant actívíty and oxygen radical absorbance capacíty). The ethanolíc extract of ilie peel showed slgnlãcam effect 00 reducíng rhe tumoral cell growth and proliferation. Antlprolíferauve activlty of phytochemícals showed no sígnífícant correlauve relatíons wiili total phcnolíc compounds. flavonoíds and anthocyaníns, demonstratíng which lhe anuproliferative effect of the e.xtract could be due to the synergic act:ion among the compounds in redjambo peel