Jaboticaba peel: Antioxidant compounds, antiproliferative and antimutagenic activities

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)This paper reports on the anthocyanin and antioxidant contents, an the 'in vitro' antiproliferative and 'in vivo' mutagenic/antimutagenic activities of freeze-dried jaboticaba peel (JP). According to the proximate composition, JP showed a high dietary fiber content. The identification and quantification of the JP anthocyanins was carried out by HPLC-PDA and LC-MS/MS, which revealed the presence of two compounds: delphinidin 3-glucoside and cyanidin 3-glucoside (634.75 and 1963.57 mg 100 g(-1) d. w., respectively). JP showed a strong antioxidant potential: 25,514.24+/-3037 mu M TE g(-1), 45.38+/-0.50 mu g mL(-1) and 9458+/-97 mu M TEAC g(-1), for ORAC, DPPH and ABTS, respectively. The polar JP extract demonstrated antiproliferative effects against leukemia (K-562), and the non-polar extract was the most active against prostate cancer cell (PC-3), according to the antiproliferative assay. The micronucleus test in mice demonstrated that the polar JP extract induced no DNA damage and hence it showed no cytotoxic properties on mice bone marrow cells and caused no mutagenic effects. (C) 2012 Elsevier Ltd. All rights reserved.491596603Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FINEPConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP