Haematinic activity of Keezhanelli Chooranam and Annabedi Chenduram

AIM & OBJECTIVE: The aim of this dissertation is to establish that the Keezhanelli is an effective drug of haematinic activity based on its indication for ‘PANDU’ mentioned in “Koshayi Anuboga vaithiya Bhramma Ragasiyam” Part – II Page no. 144. It is commonly known drug for hepatitis and jaundice. But its haematinic activity hitherto is not evaluated pharmacologically and clinically. Thanks to its tremendous availability it can be easily used by proletariats and downtroddens if its property of haematinic activity is duly proved. This study is done in the following aspects: 1. Gunapadam aspect, 2. Botanical aspect, 3. Biochemical analysis, 4. Pharmacological analysis, 5. Clinical assessment. MATERIALS & METHODS: Drug Selection: In this dissertation the whole plant Keezhanelli (Phyllanthus amarus) was taken as single drug for study for “PANDU” on the basis of haematinic activity. Collection of Drug: The whole plant of Phyllanthus amarus was collected from the agricultural lands in and around of Palayamkottai. Preparation of the drug: The whole plant was dried for a week in the shade. The dried plant was made into fine powder and filtered by white cloth (Vasthirakayam). Purification of the Choornam: An earthern pot was taken and was filled with milk diluted with equal part of water. A cloth was tied round the mouth of the pot. The prepared Choornam was placed over the cloth and then is covered with another earthern pot. It was kept on stove until milk level decrease. The choornam was taken out and dried. Route of Administration: Enteral route. Dose: 1 gm with hot water thrice daily. SUMMARY: The test drug Annabedi chenduram was selected to find out its haematinic activity in Pandu noi. The dose is 120mg with honey. The basic informations about the test drug collected from various Siddha literatures were reviewed. Bio chemical analysis established that the drug contains sulphate, chloride. Carbonate, unsaturated compounds. It also contains iron in ferrous form. Pharmacological study reveals significant effect of haematinic activity of the test drug. In the clinical study 40 patients were taken. Among them 75% of patients showed good response. During the clinical trial some patients had constipation. No other side effects were seen. The patients were advised to abstain from the trial drug on the 8th day following the successive seven days of treatment in accordance with Siddha literature. Thus the test drug Annabedi chenduram is found to be an effective and safe drug for Pandu noi on the basis of haematinic activity. CONCLUSION: It is concluded that the test drug Annabedi Chenduram has got significant haematinic activity. So it is clinically very effective in Pandu noi