Hepatoprotective activity of Maavilingapattai Chooranam on CCl4, Paracetamol and Ethanol Induced Hepatotoxicity in In-vivo models

The test drug Maavilingapattai Chooranam was selected from the Siddha literature Sirorathina Vaidhiya Booshanam written by Angamuthu Mudhaliyar for its hepatoprotective activity. • The dissertation started with an introduction explaining about the Siddha concept, prevalence of jaundice and role of the test drug in treating hepatic diseases. • The review of literature strengthened the positive facts of possessing the Hepatoprotective activity by each of the single drug included in the formulation. • The pharmacological review possessed all the information regarding the exertion of action of the drugs, available drugs in the market, their adverse effects. • The test drug Maavilingapattai Chooranam was prepared properly by the given procedure. • All the ingredients were identified and authenticated by the experts. • Review of literature in various categories was carried out. Siddha aspect, botanical aspect and pharmaceutical review disclosed about the drug and the disease. • Pharmacological review was done to establish the methodologies. • The drug was subjected to analysis such as physicochemical, phytochemical, biochemical and also instrumental analysis which provided the key ingredients present in the drug thus it accounts the efficacy of the drug. • Toxicological study was made according to OECD guidelines comprising both acute and sub-acute toxicity study. It showed the safety of the drug which attributes its utility in long time administration. • Pharmacological study was done. It revealed the Hepatoprotective activity of Maavilingapattai Chooranam in animal model Wistar albino rats. • Results and discussion gives the necessary justifications to prove the potency of the drug. • Conclusion gives a compiled form of the study and explains the synergistic effect of all the key ingredients and activities that supports the study. • This current analysis authenticates that Maavilingapattai Chooranam has impressive Hepatoprotective activity, which exemplifies the intelligence of the Siddha literature to reach globally for the welfare of mankind. Thus the herbal formulation Maavilingapattai Chooranam is validated for its safety and efficacy for treating jaundice and it would be a great drug of choice