Add to ORKGAbstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical metastatic model of melanoma. Additionally, we aimed to investigate the combinatorial effect of histamine and gamma radiation on the radiobiological response of melanoma cells. Results indicate that 1205Lu metastatic melanoma cells express H4R and that histamine inhibits proliferation, in part through the stimulation of the H4R, and induces cell senescence and melanogenesis. Daily treatment with H4R agonists (1 mg/kg, sc) exhibited a significant in vivo antitumor effect and importantly, compounds reduced metastatic poten...
Abstract: Breast cancer is the second most common cancer worldwide, and the leading cause of cancer ...
Abstract: In the present review, we will discuss the recent advances in the understanding of the rol...
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the r...
Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma prolifer...
Functional presence of histamine H4 receptor (H4R) was demonstrated in human melanoma cell lines an...
We have previously reported that histamine at micromolar concentrations reduces the proliferation of...
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of hista...
Cancer is a leading cause of death in both developed and developing countries. Although advances in ...
Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in w...
The presence of the histamine H₄ receptor (H₄R) was previously reported in benign and malignant lesi...
Since histamine discovery in 1910, it has been recognized as a major mediator in gastric acid secret...
The radioprotective potential of histamine on healthy tissue has been previously demonstrated. The a...
Abstract: The discovery of the human histamine H4 receptor (H4R) has contributed to our understandin...
Abstract: Cancer is a leading cause of death in both developed and developing countries. Although a...
It is well known that histamine is a key regulator of inmune cell functions and it also modulates ca...
Abstract: Breast cancer is the second most common cancer worldwide, and the leading cause of cancer ...
Abstract: In the present review, we will discuss the recent advances in the understanding of the rol...
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the r...
Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma prolifer...
Functional presence of histamine H4 receptor (H4R) was demonstrated in human melanoma cell lines an...
We have previously reported that histamine at micromolar concentrations reduces the proliferation of...
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of hista...
Cancer is a leading cause of death in both developed and developing countries. Although advances in ...
Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in w...
The presence of the histamine H₄ receptor (H₄R) was previously reported in benign and malignant lesi...
Since histamine discovery in 1910, it has been recognized as a major mediator in gastric acid secret...
The radioprotective potential of histamine on healthy tissue has been previously demonstrated. The a...
Abstract: The discovery of the human histamine H4 receptor (H4R) has contributed to our understandin...
Abstract: Cancer is a leading cause of death in both developed and developing countries. Although a...
It is well known that histamine is a key regulator of inmune cell functions and it also modulates ca...
Abstract: Breast cancer is the second most common cancer worldwide, and the leading cause of cancer ...
Abstract: In the present review, we will discuss the recent advances in the understanding of the rol...
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the r...