Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer
- Martinel Lamas, Diego José
- Cortina, Jorge E.
- Ventura, Clara
- Sterle, Helena Andrea
- Valli, Eduardo
- Balestrasse, Karina Beatriz
- Blanco, Horacio Alejandro
- Cremaschi, Graciela Alicia
- Rivera, Elena Susana
- Medina, Vanina Araceli
DOIAbstract
The radioprotective potential of histamine on healthy tissue has been previously demonstrated. The aims of this work were to investigate the combinatorial effect of histamine or its receptor ligands and gamma radiation in vitro on the radiobiological response of 2 breast cancer cell lines (MDA-MB-231 and MCF-7), to explore the potential molecular mechanisms of the radiosensitizing action and to evaluate the histamine-induced radiosensitization in vivo in a triple negative breast cancer model. Results indicate that histamine significantly increased the radiosensitivity of MDA-MB-231 and MCF-7 cells. This effect was mimicked by the H1R agonist 2-(3-(trifluoromethyl)phenyl)histamine and the H4R agonists (Clobenpropit and VUF8430) in MDA-MB-231...
Add to ORKG