The subject of this paper is a fragmentation equation with non-conservative solutions, some mass being lost to a dust of zero-mass particles as a consequence of an intensive splitting. Under some assumptions of regular variation on the fragmentation rate, we describe the large-time behavior of solutions. Our approach is based on probabilistic tools: the solutions to the fragmentation equation are constructed via non-increasing self-similar Markov processes that reach continuously 0 in finite time. Our main probabilistic result describes the asymptotic behavior of these processes conditioned on non-extinction and is then used for the solutions to the fragmentation equation. We notice that two parameters influence significantly these large-...