We analyze Granger causality testing in mixed-frequency VARs with possibly (co)integrated time series. It is well known that conducting inference on a set of parameters is dependent on knowing the correct (co)integration order of the processes involved. Corresponding tests are, however, known to often suffer from size distortions and/or a loss of power. Our approach, which boils down to the mixed-frequency analogue of the one by Toda and Yamamoto (1995) or Dolado and Lutkepohl (1996), works for variables that are stationary, integrated of an arbitrary order, or cointegrated. As it only requires an estimation of a mixed-frequency VAR in levels with appropriately adjusted lag length, after which Granger causality tests can be conducted using ...