It is a classic topic in time series econometrics to test Granger causality among multiple variables. While many Granger causality tests have been invented in the literature, they are often vulnerable to temporal aggregation which potentially generates or hides causality. Based on the growing literature of Mixed Data Sampling (MIDAS) analysis, this dissertation proposes a set of mixed frequency Granger causality tests which are robust against temporal aggregation. The mixed frequency causality tests take an explicit treatment of data sampled at different frequencies, and hence enable more accurate statistical inference than the conventional approach that aggregates all time series into the common lowest frequency. Depending on the magnitude...