Microbial DNA in the cytosol induces production of interferon-β (IFN-β) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-β production and innate immunity
Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by...
Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for...
Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectiou...
SummaryType I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid...
SummaryType I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid...
SummaryNucleic acid recognition upon viral infection triggers type I interferon production. Viral RN...
DNA was known to stimulate immune responses long before it was shown to be a genetic material, but t...
Host defense against foreign genetic elements is one of the most funda-mental functions of a living ...
SummaryNucleic acid recognition upon viral infection triggers type I interferon production. Viral RN...
<p>(A) Cytosolic DNA from invading viruses and bacteria engage and activate AIM2 binding to the adap...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
Upon infection with a virus, a cellular innate immune response is rapidly initiated to contain the p...
Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
When a pathogen attacks, the immune system rapidly mobilizes host defenses in order to reduce the mi...
Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by...
Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for...
Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectiou...
SummaryType I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid...
SummaryType I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid...
SummaryNucleic acid recognition upon viral infection triggers type I interferon production. Viral RN...
DNA was known to stimulate immune responses long before it was shown to be a genetic material, but t...
Host defense against foreign genetic elements is one of the most funda-mental functions of a living ...
SummaryNucleic acid recognition upon viral infection triggers type I interferon production. Viral RN...
<p>(A) Cytosolic DNA from invading viruses and bacteria engage and activate AIM2 binding to the adap...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
Upon infection with a virus, a cellular innate immune response is rapidly initiated to contain the p...
Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
When a pathogen attacks, the immune system rapidly mobilizes host defenses in order to reduce the mi...
Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by...
Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for...
Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectiou...
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