Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell signaling pathogenic invasion. In response, innate immune DNA-sensing pathways launch an antimicrobial type I interferon (IFN) response, which becomes damaging to the host if unregulated or inappropriately activated by self-DNA. This Select highlights recent insights into activation and regulation of innate immune DNA-sensing pathways
The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa e...
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host d...
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate immune rec...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it is only...
<p>(A) Cytosolic DNA from invading viruses and bacteria engage and activate AIM2 binding to the adap...
Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the ...
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGA...
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA r...
SummaryNucleic acid recognition upon viral infection triggers type I interferon production. Viral RN...
Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of I...
Self-DNA has previously been thought to be protected from immune detection by compartmentalisation i...
Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA ...
Innate immunity is the first line of host defense against invading pathogens. The detection of aberr...
The presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting th...
The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa e...
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host d...
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate immune rec...
Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell si...
Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it is only...
<p>(A) Cytosolic DNA from invading viruses and bacteria engage and activate AIM2 binding to the adap...
Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the ...
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGA...
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA r...
SummaryNucleic acid recognition upon viral infection triggers type I interferon production. Viral RN...
Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of I...
Self-DNA has previously been thought to be protected from immune detection by compartmentalisation i...
Cyclic GMP-AMP synthase (cGAS) is best known as an innate immune receptor that detects pathogen DNA ...
Innate immunity is the first line of host defense against invading pathogens. The detection of aberr...
The presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting th...
The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa e...
Detection of microbial nucleic acids via innate immune receptors is critical for establishing host d...
Rapid detection of microbes is crucial for eliciting an effective immune response. Innate immune rec...
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