A and B, Immunostaining of TGFβ and p-SMAD2/3 in Ptenf/fLtfCre/+ and Ptenf/fPgrCre/+ uteri. Nuclei are counterstained with Hoechst (blue). Experiments were performed in three mice, and representative images are presented. C. RNA levels of TGFβ and its target genes in patients with uterine corpus endometrial carcinoma (UCEC) from TCGA database. Scale bars, 200 μm. le, luminal epithelium; ge, glandular epithelium; s, stroma; myo, myometrium. *, p<0.05; ***, p<0.01.</p
(A) Itga1 mRNA levels were elevated in TGFBR1CA flox/flox; PgrCre/+ uteri at D7. (B) Col1a1, Itga1 a...
(A-L) Immunolocalization of KRT8 (green) and ACTA2 (red) in the uteri of control and TGFBR1CA flox/f...
We hypothesized that transforming growth factor β1 (TGFβ 1) and its receptors play a role in the int...
Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the u...
Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the u...
A, Immunostaining of Ki67 and CK8. The expression of Ki67 show increased proliferation in Ptenf/fLtf...
TGF-β has a dichotomous function, acting as tumor suppressor in premalignant cells but as a tumor pr...
A-C, Increased p-AKT, pS6 and COX-2 signals are observed in the epithelium of Ptenf/fLtfCre/+ and Pt...
A, Immunohistochemistry of PTEN in 2 and 3-month-old Ptenf/f and Ptenf/fLtfCre/+ uteri. Arrow, PTEN ...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Transforming growth factor beta (TGFβ) superfamily signaling regulates multiple reproductive events....
Endometrial cancer is one of the leading gynecological cancers diagnosed among women in their menopa...
Decidualization is an intricate biological process where extensive morphological, functional, and ge...
(A-F) Immunofluorescence detection of FOXA2 (red) and KRT8 (green) in the uteri of control and TGFBR...
The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apo...
(A) Itga1 mRNA levels were elevated in TGFBR1CA flox/flox; PgrCre/+ uteri at D7. (B) Col1a1, Itga1 a...
(A-L) Immunolocalization of KRT8 (green) and ACTA2 (red) in the uteri of control and TGFBR1CA flox/f...
We hypothesized that transforming growth factor β1 (TGFβ 1) and its receptors play a role in the int...
Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the u...
Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the u...
A, Immunostaining of Ki67 and CK8. The expression of Ki67 show increased proliferation in Ptenf/fLtf...
TGF-β has a dichotomous function, acting as tumor suppressor in premalignant cells but as a tumor pr...
A-C, Increased p-AKT, pS6 and COX-2 signals are observed in the epithelium of Ptenf/fLtfCre/+ and Pt...
A, Immunohistochemistry of PTEN in 2 and 3-month-old Ptenf/f and Ptenf/fLtfCre/+ uteri. Arrow, PTEN ...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Transforming growth factor beta (TGFβ) superfamily signaling regulates multiple reproductive events....
Endometrial cancer is one of the leading gynecological cancers diagnosed among women in their menopa...
Decidualization is an intricate biological process where extensive morphological, functional, and ge...
(A-F) Immunofluorescence detection of FOXA2 (red) and KRT8 (green) in the uteri of control and TGFBR...
The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apo...
(A) Itga1 mRNA levels were elevated in TGFBR1CA flox/flox; PgrCre/+ uteri at D7. (B) Col1a1, Itga1 a...
(A-L) Immunolocalization of KRT8 (green) and ACTA2 (red) in the uteri of control and TGFBR1CA flox/f...
We hypothesized that transforming growth factor β1 (TGFβ 1) and its receptors play a role in the int...