Increased expression of extracellular matrix related genes and fibrotic changes in <i>TGFBR1</i>^{CA flox/flox}; <i>Pgr</i>^Cre/+ uteri.

(A) Itga1 mRNA levels were elevated in TGFBR1CA flox/flox; PgrCre/+ uteri at D7. (B) Col1a1, Itga1 and Itgb1 mRNA abundance was increased in TGFBR1CA flox/flox; PgrCre/+ uteri at D31. (C) Lama1 mRNA levels were increased in TGFBR1CA flox/flox; PgrCre/+ uteri. n = 4 per group. Data are means ± SEM. *P P P D and E) Trichrome staining of uteri from control and TGFBR1CA flox/flox; PgrCre/+ mice at 1 month of age. Note increased blue staining in uterine stroma of TGFBR1CA flox/flox; PgrCre/+ mice versus controls. (F-I) Immunohistochemistry of COL-1 in the uteri from control and TGFBR1CA flox/flox; PgrCre/+ mice at 1 month of age. Negative controls using rabbit IgG are shown in (H) and (I). Three individual samples from each group were examined. Scale bar is representatively shown in (D) and equals 20 μm (D-I).