Representative images of renal 4-hydroxynonenal adducts (HNE) are shown. HNE adducts (brown) were seen in untreated ischemic (ISCH/SALINE) rats, and nearly undetectable in sham rats (SHAM). Treatment with renal cells (ISCH/CELLS) or their exosomes (ISCH/EXO) prevented HNE adduct formation. Nuclei are counterstained blue with hematoxylin. The bar diagram summarizes the results: (*), significantly higher than the sham rat group (SHAM), p < 0.05. (§), significantly lower than untreated ischemic rat group (SALINE), p < 0.05. (n = 77 measurements per group).</p
Hypertension is associated with increased reactive oxygen species (ROS). Renal ROS production and th...
4-Hydroxy-trans-2-nonenal (HNE) is a cytotoxic α,β-unsaturated aldehyde implicated in the pathology ...
A, representative frozen kidney sections of sham rats (SHAM, left), ischemic rats injected with huma...
Oxidative stress has been considered as a central aggravating factor in the development of postische...
Top, representative images of renal sections stained with Periodic acid Schiff (PAS). Left to right,...
A, representative images of renal sections labeled with anti-neutrophil antibody. Neutrophils (brown...
Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: Attenuation by dehydroep...
A, serum creatinine levels in the four groups of rats, n = 4–5. Sham (sham, open circles), untreated...
Tubular apoptosis was extensive in untreated ischemic rats (brown, ISCHEMIA/SALINE), while it was ne...
<p>(A) SV immunostained for 4-HNE adducts. Positive staining is shown in dark brownish black and det...
<p>(<b>A</b>) Representative images of 4-hydroxy-2-nonenal (4-HNE) immunostaining in the kidneys of ...
<p>A strong intracellular 4-Hne adduct immunostaining (grade 3) is detected in the liver of rats not...
<p>A. 4-HNE-stained liver sections. Representative bright-field photomicrographs of liver sections o...
<p>(A-D), Haematoxylin & Eosin Staining: Renal cortical sections showing characteristic histological...
Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological s...
Hypertension is associated with increased reactive oxygen species (ROS). Renal ROS production and th...
4-Hydroxy-trans-2-nonenal (HNE) is a cytotoxic α,β-unsaturated aldehyde implicated in the pathology ...
A, representative frozen kidney sections of sham rats (SHAM, left), ischemic rats injected with huma...
Oxidative stress has been considered as a central aggravating factor in the development of postische...
Top, representative images of renal sections stained with Periodic acid Schiff (PAS). Left to right,...
A, representative images of renal sections labeled with anti-neutrophil antibody. Neutrophils (brown...
Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: Attenuation by dehydroep...
A, serum creatinine levels in the four groups of rats, n = 4–5. Sham (sham, open circles), untreated...
Tubular apoptosis was extensive in untreated ischemic rats (brown, ISCHEMIA/SALINE), while it was ne...
<p>(A) SV immunostained for 4-HNE adducts. Positive staining is shown in dark brownish black and det...
<p>(<b>A</b>) Representative images of 4-hydroxy-2-nonenal (4-HNE) immunostaining in the kidneys of ...
<p>A strong intracellular 4-Hne adduct immunostaining (grade 3) is detected in the liver of rats not...
<p>A. 4-HNE-stained liver sections. Representative bright-field photomicrographs of liver sections o...
<p>(A-D), Haematoxylin & Eosin Staining: Renal cortical sections showing characteristic histological...
Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological s...
Hypertension is associated with increased reactive oxygen species (ROS). Renal ROS production and th...
4-Hydroxy-trans-2-nonenal (HNE) is a cytotoxic α,β-unsaturated aldehyde implicated in the pathology ...
A, representative frozen kidney sections of sham rats (SHAM, left), ischemic rats injected with huma...