Oxidative stress evaluated by 4-hydroxynonenal (4-HNE) staining is selectively up-regulated in CCl₄-treated liver.

<p>A. 4-HNE-stained liver sections. Representative bright-field photomicrographs of liver sections of control and CCl₄-treated mice immunostained for 4-HNE. 4-HNE staining is evident in many lobular hepatocytes in CCl₄-treated mice. B. 4-HNE-stained lung sections. Representative bright-field micrographs of 4-HNE-immunostained lung sections from control and CCl₄-treated mice. In contradistinction to robust liver staining, no 4-HNE can be detected in the lungs of mice treated with CCl₄. Scale bar = 100 µm.