Changes in body length and body weight of female WT and CNP-KO rats that received vehicle or CNP-53 for 28 days.

Changes in naso-anal body length (Δ body length) in CNP-KO rats (A) and WT rats (B), and changes in body weight (Δ body weight) in CNP-KO rats (C) and WT rats (D). Each value shown is the mean + SE. Open circles, vehicle (n = 5 and 7 in CNP-KO and WT rats, respectively); closed triangles, CNP-53 0.15 mg/kg/day (n = 4 in the both genotypes); closed squares, CNP-53 0.5 mg/kg/day (n = 6 in the both genotypes). *, p p < 0.01 vs. vehicle-treated group based on Dunnett’s multiple comparison test.