(A) Body weight and length, (B) relative lengths of craniofacial morphology to WT rats, (C) relative size of foramen magnum to WT rats. WT, WT rats which received vehicle; CNP-KO, CNP-KO rats which received vehicle; CNP-KO + CNP, CNP-KO rats which received CNP-53 (ca. 0.5 mg/kg/day). Data are expressed as the means ± SD of 4–5 rats. *, P P t-test.</p
Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B, is a...
(A) 3D-reconstructed images of the foramen magnum in WT and CNP-KO rats at 9 weeks of age, and in SD...
(A) Linear measurements for analysis of skull morphology. (B) 3D-reconstructed images of WT, CNP-KO,...
Effect of CNP-53 on body length and body weight in female CNP-KO and WT rats.</p
Effect of CNP-53 on body length and body weight in male and female CNP-KO rats.</p
(A) The bone volume density (BV/TV), (B) trabecular thickness (Tb.Th), and (C) trabecular number (Tb...
Changes in naso-anal body length (Δ body length) in CNP-KO rats (A) and WT rats (B), and changes in ...
(A) Soft x-ray images of 8-week-old CNP-KO and WT rats. (B), (C) Bone lengths (B) and especially tho...
(A) Plasma osteocalcin levels, and (B) plasma TRAP5b levels. The values are the means + SE. Open bar...
(A) Representative example of the proximal end of the tibia stained with alcian blue/HE. The white a...
C-type natriuretic peptide (CNP)-knockout (KO) rats exhibit impaired skeletal growth, with long bone...
<p>No differences in spine head diameter were detected between saline- (n = 3) and CNO-treated (n = ...
Histological micrographs of the distal end of the tibia (A) and the calcaneus (B). KO vehicle, CNP-K...
Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B, is a...
PK parameters of CNP immunoreactivity after a single subcutaneous administration of CNP(1–22) or ASB...
Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B, is a...
(A) 3D-reconstructed images of the foramen magnum in WT and CNP-KO rats at 9 weeks of age, and in SD...
(A) Linear measurements for analysis of skull morphology. (B) 3D-reconstructed images of WT, CNP-KO,...
Effect of CNP-53 on body length and body weight in female CNP-KO and WT rats.</p
Effect of CNP-53 on body length and body weight in male and female CNP-KO rats.</p
(A) The bone volume density (BV/TV), (B) trabecular thickness (Tb.Th), and (C) trabecular number (Tb...
Changes in naso-anal body length (Δ body length) in CNP-KO rats (A) and WT rats (B), and changes in ...
(A) Soft x-ray images of 8-week-old CNP-KO and WT rats. (B), (C) Bone lengths (B) and especially tho...
(A) Plasma osteocalcin levels, and (B) plasma TRAP5b levels. The values are the means + SE. Open bar...
(A) Representative example of the proximal end of the tibia stained with alcian blue/HE. The white a...
C-type natriuretic peptide (CNP)-knockout (KO) rats exhibit impaired skeletal growth, with long bone...
<p>No differences in spine head diameter were detected between saline- (n = 3) and CNO-treated (n = ...
Histological micrographs of the distal end of the tibia (A) and the calcaneus (B). KO vehicle, CNP-K...
Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B, is a...
PK parameters of CNP immunoreactivity after a single subcutaneous administration of CNP(1–22) or ASB...
Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B, is a...
(A) 3D-reconstructed images of the foramen magnum in WT and CNP-KO rats at 9 weeks of age, and in SD...
(A) Linear measurements for analysis of skull morphology. (B) 3D-reconstructed images of WT, CNP-KO,...