Additional file 8: of CD38 is methylated in prostate cancer and regulates extracellular NAD+
- Jack Mottahedeh (5119268)
- Michael Haffner (5779562)
- Tristan Grogan (628047)
- Takao Hashimoto (662481)
- Preston Crowell (5779565)
- Himisha Beltran (5779568)
- Andrea Sboner (180596)
- Rohan Bareja (5779571)
- David Esopi (4347547)
- William Isaacs (4458526)
- Srinivasan Yegnasubramanian (27577)
- Matthew Rettig (146731)
- David Elashoff (195366)
- Elizabeth Platz (3624092)
- Angelo De Marzo (200674)
- Michael Teitell (5779574)
- Andrew Goldstein (5779577)
Publication date
September 2018
DOIAbstract
NAMPT inhibitor FK866 depletes NAD+ levels and impairs proliferation. (a, b, d, e, g, h) Intracellular NAD+ and NADH levels were measured in the presence of the indicated concentrations of FK866 in LNCaP (a, b), DU145 (d, e) and PC3 (g, h) cells. Mean ± SEM of 4 replicates is shown. Newman-Keuls Multiple Comparison Test. (c, f, i) Cell proliferation assay over 4 days in culture in the presence of the indicated concentrations of FK866 in LNCaP (c), DU145 (f) and PC3 (i) cells. DNA fluorescence represents relative cell number. 3–6 replicate wells per group per time point were measured. Mean ± SEM is shown. (TIF 131 kb
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