The administration of CORM-2 alleviates signs of neuropathic pain displayed by diabetic mice.

Antinociceptive effects produced by the intraperitoneal administration of CORM-2 at 5 or 10 mg/kg in STZ injected mice. Results are shown as the mean values ± SEM; n = 6 animals per group. The development of mechanical allodynia (A), thermal hyperalgesia (B) and thermal allodynia (C) in the hind paws of control and diabetic mice intraperitoneally treated with vehicle or CORM-2 at 5 or 10 mg/kg is represented. Data of tests are shown at day 0 (before diabetes induction) and at days 21 and 25 after Stz injection (one and five days after initiation of CORM-2 administration, respectively). For each test and day, * indicates significant differences vs. Ctrl-vehicle, # vs. Stz-vehicle treated mice and † vs. Stz mice treated with 5 mg/kg CORM-2 (p 0.05, one-way ANOVA followed by a Student-Newman-Keuls test). CORM-2, (tricarbonyldichlororuthenium(II) dimer; Ctrl, control mice; Stz, streptozotocin treated mice.