Additional file 6: Figure S3. Backcrossing of R57 with wild type cells generates strains presenting a wide spectrum of fitness in SSL. Growth in the presence and absence of SSL is reported for R57, various wild type cell types and 86 F2 isolates from backcrossing of R57 and CEN.PK113-1A. Error bars represent plus or minus one standard deviation. The dashed line is a visual reference for the level achieved by the wildtype
These data sets are generated to investigate a simple evolutionary landscape that arises from underd...
The nature of selection acting on a population is in large measure determined by the distribution of...
Recent genome sequencing efforts have revealed astounding genetic diversity between individuals in t...
Additional file 8: Figure S5. Single mutations are not sufficient to detect an increase in SSL toler...
Additional file 7: Figure S4. Genotyping of second generation segregants from backcrossing of R57 an...
Additional file 9: Figure S6. Reversion of nrg1 and gsh1 mutations leads to loss of the SSL toleranc...
Additional file 5: Supporting methods. Detailed methods are provided for our SNP calling methodolog...
Additional file 1: Table S1. Population sequencing and alignment metrics. Table S2. Amplicon sequenc...
Additional file 2. List of single nucleotide polymorphisms detected by whole population sequencing
Additional file 4: Figure S2. Evolutionary trajectories and apparent selection of all mutation hotsp...
Most phenotypic traits are controlled by many genes, but a global picture of the genotype–phenotype ...
Although the fission yeast Schizosaccharomyces pombe is a well-established model organism, studies o...
(a) Simplified schematic of the cell-type specification circuit in Saccharomyces as determined by th...
I report on three studies where I identify signatures of natural selection in humans, and dissect th...
Mutation accumulation Eight independent lines were derived from a single haploid ancestor derived fr...
These data sets are generated to investigate a simple evolutionary landscape that arises from underd...
The nature of selection acting on a population is in large measure determined by the distribution of...
Recent genome sequencing efforts have revealed astounding genetic diversity between individuals in t...
Additional file 8: Figure S5. Single mutations are not sufficient to detect an increase in SSL toler...
Additional file 7: Figure S4. Genotyping of second generation segregants from backcrossing of R57 an...
Additional file 9: Figure S6. Reversion of nrg1 and gsh1 mutations leads to loss of the SSL toleranc...
Additional file 5: Supporting methods. Detailed methods are provided for our SNP calling methodolog...
Additional file 1: Table S1. Population sequencing and alignment metrics. Table S2. Amplicon sequenc...
Additional file 2. List of single nucleotide polymorphisms detected by whole population sequencing
Additional file 4: Figure S2. Evolutionary trajectories and apparent selection of all mutation hotsp...
Most phenotypic traits are controlled by many genes, but a global picture of the genotype–phenotype ...
Although the fission yeast Schizosaccharomyces pombe is a well-established model organism, studies o...
(a) Simplified schematic of the cell-type specification circuit in Saccharomyces as determined by th...
I report on three studies where I identify signatures of natural selection in humans, and dissect th...
Mutation accumulation Eight independent lines were derived from a single haploid ancestor derived fr...
These data sets are generated to investigate a simple evolutionary landscape that arises from underd...
The nature of selection acting on a population is in large measure determined by the distribution of...
Recent genome sequencing efforts have revealed astounding genetic diversity between individuals in t...