Additional file 9: Figure S6. Reversion of nrg1 and gsh1 mutations leads to loss of the SSL tolerance phenotype in haploid single mutants. Area under the growth curve for nrg1 and gsh1 double mutants, haploid (nrg1 gsh1) and diploid (nrg1/nrg1 gsh1/GSH1) is also reported. Error bars represent plus or minus one standard deviation. The dashed line is a visual reference for the level achieved by the wildtype
During mismatch repair (MMR) MSH proteins bind to mismatches that form as the result of DNA replicat...
Recent genome sequencing efforts have revealed astounding genetic diversity between individuals in t...
Mutation accumulation Eight independent lines were derived from a single haploid ancestor derived fr...
Additional file 8: Figure S5. Single mutations are not sufficient to detect an increase in SSL toler...
Additional file 6: Figure S3. Backcrossing of R57 with wild type cells generates strains presenting ...
Additional file 7: Figure S4. Genotyping of second generation segregants from backcrossing of R57 an...
Additional file 4: Figure S2. Evolutionary trajectories and apparent selection of all mutation hotsp...
Additional file 5: Supporting methods. Detailed methods are provided for our SNP calling methodolog...
Additional file 2. List of single nucleotide polymorphisms detected by whole population sequencing
Additional file 1: Table S1. Population sequencing and alignment metrics. Table S2. Amplicon sequenc...
Figure S3. Distribution of non-essential deletion mutants with fitness defects. Dark gray and light ...
Although the fission yeast Schizosaccharomyces pombe is a well-established model organism, studies o...
Independently evolving populations may adapt to similar selection pressures via different genetic ch...
Expression values for all the genes disomic strains relative to wild-type control from [25] compared...
Most phenotypic traits are controlled by many genes, but a global picture of the genotype–phenotype ...
During mismatch repair (MMR) MSH proteins bind to mismatches that form as the result of DNA replicat...
Recent genome sequencing efforts have revealed astounding genetic diversity between individuals in t...
Mutation accumulation Eight independent lines were derived from a single haploid ancestor derived fr...
Additional file 8: Figure S5. Single mutations are not sufficient to detect an increase in SSL toler...
Additional file 6: Figure S3. Backcrossing of R57 with wild type cells generates strains presenting ...
Additional file 7: Figure S4. Genotyping of second generation segregants from backcrossing of R57 an...
Additional file 4: Figure S2. Evolutionary trajectories and apparent selection of all mutation hotsp...
Additional file 5: Supporting methods. Detailed methods are provided for our SNP calling methodolog...
Additional file 2. List of single nucleotide polymorphisms detected by whole population sequencing
Additional file 1: Table S1. Population sequencing and alignment metrics. Table S2. Amplicon sequenc...
Figure S3. Distribution of non-essential deletion mutants with fitness defects. Dark gray and light ...
Although the fission yeast Schizosaccharomyces pombe is a well-established model organism, studies o...
Independently evolving populations may adapt to similar selection pressures via different genetic ch...
Expression values for all the genes disomic strains relative to wild-type control from [25] compared...
Most phenotypic traits are controlled by many genes, but a global picture of the genotype–phenotype ...
During mismatch repair (MMR) MSH proteins bind to mismatches that form as the result of DNA replicat...
Recent genome sequencing efforts have revealed astounding genetic diversity between individuals in t...
Mutation accumulation Eight independent lines were derived from a single haploid ancestor derived fr...