(A) Representative confocal images of CD68 (green) with DAPI (blue) (original magnification; ×200, scale bar; 100μm) and the number of CD68-positive cells per high power field of each group (n = 8, 8, 6, 8, 6 and 8 in WT-NC, WT-HC, WT-HM, FPR1-/- -NC, FPR1-/- -HC and FPR1-/- -HM, respectively). (B) Representative confocal images of myeloperoxidase (MPO; green) positive cells with DAPI (blue) and the number of MPO-positive cells per high power field (n = 8, 8, 6, 8, 6 and 8 in WT-NC, WT-HC, WT-HM, FPR1-/- -NC, FPR1-/- -HC and FPR1-/- -HM, respectively). WT-NC, wild type mice of normoxia control; WT-HC, wild type mice of hyperoxia control; WT-HM, wild type mice of hyperoxia with MSCs; FPR1-/- -NC, FPR1 knockout mice of normoxia control; FPR1-...
<p>(A) Positive immunostaining for MAC-3 confirms that the free alveolar cells are predominantly mac...
<p>(A) Identification of live (eFluor780<sup>−</sup>) AM (CD45<sup>+</sup>CD11c<sup>+</sup>Siglec-F<...
<p>β<sub>2</sub>m<sup>-/-</sup> mice or C57BL/6 controls were footpad-infected with <i>O</i>. <i>tsu...
<p>(A-B) The bar graphs show the mean (+SEM) (A) lung and (B) BALF neutrophil numbers 10 h and 36 h ...
<p>Mice of each group were sacrificed post-challenge and lungs were collected for histopathology (a-...
<p><b>(A)</b> Frozen sections of lungs harvested at 3 dpi from F.n. infected WT or Gal-9<sup>-/-</su...
<p>Representative images of lung histology from (A) CTL (B) Sham and (C) CDC- treated animals. Image...
<p>Representative Ly6-C/G stainings of lung sections obtained 6 h after induction of pneumococcal pn...
<p>Representative photomicrographs of lung histology (H&E stain) of NB MIF KO, MIF TG and WT control...
<p>Mouse lung PECAM-1 immunostaining (<b>A</b>). (<b>B</b>) Number of vessels per 100 alveoli. (<b>C...
<p>The first column shows wild type and the second column shows RAGE KO lungs. Macrophages (arrows) ...
<p>Groups of 4 C57BL/6 mice were infected with either 10<sup>3</sup> or 10<sup>6</sup> NMII. Prior t...
<p><b>A</b>: Myeloperoxidase was considered a surrogate marker of neutrophilic infiltration of lung ...
<p>Bronchoalveolar lavage (BAL) fluid was collected from WT and ASK1 KO mice (n = 4 per each group) ...
<p>Quantification of (A) neutrophils and (B) macrophages on micrographs as described in the legend t...
<p>(A) Positive immunostaining for MAC-3 confirms that the free alveolar cells are predominantly mac...
<p>(A) Identification of live (eFluor780<sup>−</sup>) AM (CD45<sup>+</sup>CD11c<sup>+</sup>Siglec-F<...
<p>β<sub>2</sub>m<sup>-/-</sup> mice or C57BL/6 controls were footpad-infected with <i>O</i>. <i>tsu...
<p>(A-B) The bar graphs show the mean (+SEM) (A) lung and (B) BALF neutrophil numbers 10 h and 36 h ...
<p>Mice of each group were sacrificed post-challenge and lungs were collected for histopathology (a-...
<p><b>(A)</b> Frozen sections of lungs harvested at 3 dpi from F.n. infected WT or Gal-9<sup>-/-</su...
<p>Representative images of lung histology from (A) CTL (B) Sham and (C) CDC- treated animals. Image...
<p>Representative Ly6-C/G stainings of lung sections obtained 6 h after induction of pneumococcal pn...
<p>Representative photomicrographs of lung histology (H&E stain) of NB MIF KO, MIF TG and WT control...
<p>Mouse lung PECAM-1 immunostaining (<b>A</b>). (<b>B</b>) Number of vessels per 100 alveoli. (<b>C...
<p>The first column shows wild type and the second column shows RAGE KO lungs. Macrophages (arrows) ...
<p>Groups of 4 C57BL/6 mice were infected with either 10<sup>3</sup> or 10<sup>6</sup> NMII. Prior t...
<p><b>A</b>: Myeloperoxidase was considered a surrogate marker of neutrophilic infiltration of lung ...
<p>Bronchoalveolar lavage (BAL) fluid was collected from WT and ASK1 KO mice (n = 4 per each group) ...
<p>Quantification of (A) neutrophils and (B) macrophages on micrographs as described in the legend t...
<p>(A) Positive immunostaining for MAC-3 confirms that the free alveolar cells are predominantly mac...
<p>(A) Identification of live (eFluor780<sup>−</sup>) AM (CD45<sup>+</sup>CD11c<sup>+</sup>Siglec-F<...
<p>β<sub>2</sub>m<sup>-/-</sup> mice or C57BL/6 controls were footpad-infected with <i>O</i>. <i>tsu...