Predicted protein primary and secondary structures.

(A) The protein coding sequence of zebrafish Psen2 is altered by the mutations. (B) The predicted protein structures of zebrafish Psen2 are also changed by the two identified mutations (and are shown relative to the wild type structure and a structure incorporating a hypothetical N140I mutation. Purple bar: helix; yellow arrow: strand; black line: coil; Conf: confidence of prediction; Pred: predicted secondary structure; AA: target sequence.