Nonsense mutations in zebrafish <i>ptpn11a</i> and <i>ptpn11b</i>.
- Monica Bonetti (552098)
- Virginia Rodriguez-Martinez (552099)
- Jeroen Paardekooper Overman (552100)
- John Overvoorde (242505)
- Mark van Eekelen (170347)
- Chris Jopling (59402)
- Jeroen den Hertog (59407)
Publication date
April 2014
DOIAbstract
<p>Sequence analysis of homozygous <i>ptpn11a</i> and <i>ptpn11b</i> mutants. (a) A C to T mutation in <i>ptpn11ahu3459</i> resulted in a glutamine to a STOP mutation. (b) A T to A mutation in <i>ptpn11bhu5920</i> changed lysine to a STOP mutation. (c) Schematic representation of the exon organization and structural domains of <i>ptpn11a</i> and <i>ptpn11b</i>. Nonsense mutations upstream of the catalytic domain are represented by red arrows.</p
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