Biological activity of key compounds with varying tail groups (denoted by R²) against <i>L</i>. <i>major</i> amastigote, <i>T</i>.<i>b</i>. <i>brucei</i>, <i>T</i>. <i>cruzi</i> cultures and HepG2 human cells.

Data for the full screening set is summarized in the supplementary information. nd = not determined aAll r2 values are >0.9 unless noted otherwise bAll SEM values within 25% except for 1 where EC50 T. cruzi 0.73 (SEM: 0.2; 27%) cTested concentration ranges were determined based on compound solubility dSelectivity index (SI) calculated relative to HepG2 cells. eSelectivity index (SI) calculated relative to 3T3 cells.