Cytotoxicity of compounds 1–4 toward mammalian cells.

<p>^<i>a</i>CC₅₀: concentration of drug inducing 50% of cell growth arrest.</p><p>^<i>b</i>SI: Selectivity index expressed as (CC₅₀ to each mammalian cell line)/(IC₅₀ to <i>P</i>. <i>falciparum</i>). SI max corresponds to the most sensitive strain of <i>P</i>. <i>falciparum</i> and SI min toward the less sensitive parasite strain.</p><p>Cytotoxicity of compounds 1–4 toward mammalian cells.