<p><sup>a</sup><i>T</i>. <i>cruzi</i>, strain Tulahuen C4, intracellular amastigotes.</p><p><sup>b</sup>Cytotoxicity on L6 cells.</p><p><sup>c</sup>Selectivity index: IC<sub>50</sub> Cytotoxicity L6/ IC<sub>50</sub><i>T</i>. <i>cruzi</i>.</p><p>IC<sub>50</sub> values are means of two independent assays, which varied < ±50%.</p><p><i>In vitro</i> activity against <i>T</i>. <i>cruzi</i> in IC<sub>50</sub> (μM) of compounds fulfilling hit criteria.</p
<p>pEC<sub>50</sub> = –Log (EC<sub>50</sub> [M]), average of at least three biological replicates ± ...
<p>Groups of WT C57BL/6 (n = 4), WT 129 mice (n = 4), MHC-II KO (n = 4), perforin KO (n = 8), CD4 KO...
A cell-viability assay to evaluate the entry of α-sarcin in Vero cells after the incubation with EVs...
<p><sup><i>a</i></sup><i>P</i>. <i>falc</i>.: <i>P</i>. <i>falciparum</i> strain K1.</p><p><sup>b</s...
<p>Results of separate assays are separated by semicolons. The selectivity index is based on the ave...
<p>Their host cell toxicity (TC<sub>50</sub>) and anti-<i>T. cruzi</i> (IC<sub>50</sub> for the ‘Am/...
<p><sup><i>a</i></sup><i>L</i>. <i>don</i>. axen.: axenic amastigotes of <i>L</i>. <i>donovani</i>, ...
<p><sup>a</sup><i>T</i>. <i>b</i>. <i>rhod</i>.:<i>T</i>. <i>b</i>. <i>rhodesiense</i> strain STIB 9...
<p>Potencies against intracellular <i>T</i>. <i>cruzi</i> for control compounds (N = 3).</p
<p>Groups of five mice were infected with <i>T. cruzi</i> and treated with different compounds follo...
Chagas disease is caused by infection with the protozoan parasite, Trypanosoma cruzi. The disease ca...
<p>The IC50 reported from the HTS available at Pubchem and the IC50 determined in our laboratory are...
Data for the full screening set is summarized in the supplementary information. nd = not determined ...
nd = not determined aAll r2 values are >0.9 unless noted otherwise bAll SEM values within 25% except...
<p>Infected LLCMK<sub>2</sub> cells were incubated in the presence of different concentrations of qu...
<p>pEC<sub>50</sub> = –Log (EC<sub>50</sub> [M]), average of at least three biological replicates ± ...
<p>Groups of WT C57BL/6 (n = 4), WT 129 mice (n = 4), MHC-II KO (n = 4), perforin KO (n = 8), CD4 KO...
A cell-viability assay to evaluate the entry of α-sarcin in Vero cells after the incubation with EVs...
<p><sup><i>a</i></sup><i>P</i>. <i>falc</i>.: <i>P</i>. <i>falciparum</i> strain K1.</p><p><sup>b</s...
<p>Results of separate assays are separated by semicolons. The selectivity index is based on the ave...
<p>Their host cell toxicity (TC<sub>50</sub>) and anti-<i>T. cruzi</i> (IC<sub>50</sub> for the ‘Am/...
<p><sup><i>a</i></sup><i>L</i>. <i>don</i>. axen.: axenic amastigotes of <i>L</i>. <i>donovani</i>, ...
<p><sup>a</sup><i>T</i>. <i>b</i>. <i>rhod</i>.:<i>T</i>. <i>b</i>. <i>rhodesiense</i> strain STIB 9...
<p>Potencies against intracellular <i>T</i>. <i>cruzi</i> for control compounds (N = 3).</p
<p>Groups of five mice were infected with <i>T. cruzi</i> and treated with different compounds follo...
Chagas disease is caused by infection with the protozoan parasite, Trypanosoma cruzi. The disease ca...
<p>The IC50 reported from the HTS available at Pubchem and the IC50 determined in our laboratory are...
Data for the full screening set is summarized in the supplementary information. nd = not determined ...
nd = not determined aAll r2 values are >0.9 unless noted otherwise bAll SEM values within 25% except...
<p>Infected LLCMK<sub>2</sub> cells were incubated in the presence of different concentrations of qu...
<p>pEC<sub>50</sub> = –Log (EC<sub>50</sub> [M]), average of at least three biological replicates ± ...
<p>Groups of WT C57BL/6 (n = 4), WT 129 mice (n = 4), MHC-II KO (n = 4), perforin KO (n = 8), CD4 KO...
A cell-viability assay to evaluate the entry of α-sarcin in Vero cells after the incubation with EVs...