Functional effect of IL-6 on <i>I</i>_<i>Kr</i> in HEK-hERG cells.

A, Voltage-clamp protocol used to elicit IKr in HEK-hERG cells stable expressing hERG channel. B, Control hERG current. Arrows indicate hERG peak and tail currents. C, IKr currents measured in cells pre-treated with IL-6 alone or D, with IL-6+IL-6R. E, IKr peak and F, tail density-voltage- curves for control (circle, n = 21), IL-6 alone (square, n = 18) and IL-6+IL-6R (triangle, n = 9). G, The dose-response effects of IL-6+IL-6R on IKr peak and tail densities. Data were normalized to control and expressed as percentage of control.