Additional file 7: of Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

Figure S7. (A). Knockdown of circNRIP1 and miR-149-5p significantly reversed the expression levels of AKT1/mTOR pathway molecules, certain metabolism markers and EMT markers achieved by knocking down only circNRIP1 in BGC-823 cells. (B). We observed that the reduction of GC cell proliferation mediated by circNRIP1 knockdown was successfully blocked by miR-149-5p inhibition in BGC-823 cells, scale bar = 100 µm. (C). We observed that the reduction of metastasis of GC cells mediated by circNRIP1 knockdown was successfully blocked by miR-149-5p inhibition in BGC-823 cells, scale bar = 100 µm. All data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. (TIF 3849 kb