Additional file 3: of SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

Figure S3. SKP2 and PDCD4 expression in breast tumors from nude mice were detected by immunohistochemical staining. (a) Breast tumors from MCF-7-Con, MCF-7-SKP2 and MCF-7-SKP2 with PDCD4 stable expression cells were harvested from nude mice at 6 weeks for SKP2 and PDCD4 staining by IHC and quantitated (Scale bars, 50 um, Scale bars inside the box, 20 um). Data represent the mean ± SEM of three independent experiments. Student’s t-test used: *P < 0.05; **P < 0.01. (b) Breast tumors from MDA-MB-231-Con, MDA-MB-231-sgSKP2 and MDA-MB-231-sgSKP2 with shPDCD4 stable expression cells were harvested from nude mice at 6 week for SKP2 and PDCD4 staining by IHC and quantitated (Scale bars, 50 um, Scale bars inside the box, 20 um). Data represent the mean ± SEM of three independent experiments. Student’s t-test used: *P < 0.05; **P < 0.01. (TIF 31660 kb