Additional file 7: of SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

Figure S7. γ-H2AX expression in breast tumors from nude mice were detected by immunohistochemical staining. (a) Breast tumors from MCF-7 cells treated or untreated with SMIP004 or radiation were harvested from nude mice at 6 week for γ-H2AX staining by IHC and quantitated (Scale bars, 50 um, Scale bars inside the box, 20 um). Data represent the mean ± SEM of three independent experiments. Student’s t-test used: *P < 0.05; **P < 0.01. (b) Breast tumors from MDA-MB-231 cells treated or untreated with SMIP004 or radiation were harvested from nude mice at 6 week for γ-H2AX staining by IHC and quantitated (Scale bars, 50 um, Scale bars inside the box, 20 um). Data represent the mean ± SEM of three independent experiments. Student’s t-test used: *P < 0.05; **P < 0.01. (TIF 17751 kb