Additional file 6: of SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

Figure S6. SMIP004 promotes breast cancer cell apoptosis after radiation. (a, b) MCF-7 or MDA-MB-231 cells were untreated or treated with SMIP004 (40 μM) for 24 h, then untreated or treated with radiation (6GY). After 1 h, γ-H2AX expression is determined by immunostaining. DSBs were determined by analysis of γ-H2AX by immunostaining (Scale bars, 5 um). Data represent the mean ± SEM of three independent experiments. Student’s t-test used: *P < 0.05; **P < 0.01. (TIF 10302 kb