MeV passaged on a lymphocytic cell line has altered growth kinetics.

(A and B) Titers of parental (p1) and passaged viruses on Granta-519 (A) and H358 (B) cells. p1 was passaged 14 times on lymphocytes (L14) or epithelial cells (E14). One million Granta or H358 cells were infected with either p1, L14, or E14 at MOI 0.03 and harvested at 24, 48, or 72 h post infection. Titers were determined using triplicate end point dilution assays on Vero hSLAM cells. Results are shown as means ±SD of n = 3. Asterisks indicate statistically significant differences compared to p1 (**, P<0.01; Student’s t-test).