Pathogen titers and lung pathology in coinfected mice.

(A-B) Viral and bacterial titers in whole lung homogenates of coinfected mice on day 9 (day 2 after coinfection). (C) Total Lung pathology scores from coinfected mice on day 9 (day 2 after coinfection). (D-F) Lung pathology scores from coinfected mice on day 12 (day 5 after coinfection). (G) Lung histology images on day 12 (day 5 after coinfection). Original magnification is 400x (B, indicates Bronchi; Arrow, indicates region of lymphocyte infiltration). (H-K) Bacterial titers in whole lung, Liver, brain and spleen homogenates of coinfected mice on day 12 (day 5 after coinfection). Data are representative of one-two independent experiments, n = 5–9 mice per group per experiment. One-way ANOVA using Tukey’s post hoc analysis was used for statistical comparison (Mean +/- SEM). ns: not significant, p values: <0.05 (*), <0.01 (**), <0.001 (***).